⚕️ Full Prescribing Information

For complete safety information, warnings, and dosage guidelines:

View FDA Label (PDF) →

📋 Overview

Zoloft (sertraline) is one of the most commonly prescribed antidepressants. It is approved for multiple anxiety and mood disorders and has a favorable side effect profile compared to older antidepressants.

How It Works

Zoloft increases serotonin levels by blocking its reuptake in the brain, helping regulate mood, anxiety, and emotional stability.

✓ FDA Approved Uses

  • Major depressive disorder
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Post-traumatic stress disorder (PTSD)
  • Social anxiety disorder
  • Premenstrual dysphoric disorder (PMDD)

🧪 Required Lab Monitoring

Your healthcare provider will order these tests to monitor your treatment:

Liver Function Test
Baseline if history of liver disease

Need to book these tests?

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⚡ Common Side Effects

Contact your doctor if these persist or worsen:

  • Nausea
  • Diarrhea
  • Insomnia
  • Dry mouth
  • Dizziness
  • Fatigue
  • Sexual dysfunction

🚨 Serious Side Effects

Seek immediate medical attention if you experience:

  • Suicidal thoughts
  • Serotonin syndrome
  • Severe allergic reactions
  • Low sodium levels (hyponatremia)

⚠️ Do Not Use If

  • Taking MAO inhibitors
  • Taking pimozide
  • Taking disulfiram (liquid form)
  • Within 14 days of stopping MAOIs

📢 Important Warnings

  • Monitor for worsening depression or suicidal thoughts
  • Do not stop suddenly - taper under medical supervision
  • May interact with other medications

📚 Sources

Last Reviewed: April 2026